Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

TEX cell fate and differentiation are shaped by 3D genome reorganization and chromatin architecture integrity [Hi-C]

ABSTRACT: CTCF is recognized for its role in facilitating long-range chromatin interactions and 3D genome organization. In CD8+ T cells responding to chronic infection, CTCF undergoes redistribution to activate the exhausted cytotoxic effector (Tex-eff) program while simultaneously utilizing its insulation function to regulate the fate of precursors to stem-like exhausted T (Tex-prec) cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE275500 | GEO | 2026/05/19

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

TEX cell fate and differentiation are shaped by 3D genome reorganization and chromatin architecture integrity [RNA-seq]

Project description:CTCF is recognized for its role in facilitating long-range chromatin interactions and 3D genome organization. In CD8+ T cells responding to chronic infection, CTCF undergoes redistribution to activate the exhausted cytotoxic effector (Tex-eff) program while simultaneously utilizing its insulation function to regulate the fate of precursors to stem-like exhausted T (Tex-prec) cells.

2026-05-19 | GSE275499 | GEO

RNA sequencing of human CD8+ T cell subsets [TEX]

Project description:RNA sequencing of human CD8+ T cell subsets to compare hypofunctional exhausted cells (TEX) to fully activated effector cells (TEFF).

2023-07-01 | GSE234100 | GEO

Mapping self-associating chromatin hubs identifies Id proteins as key determinants of exhausted T cell fate

Project description:This study aims to define how Id2 and Id3 regulate exhausted CD8+ T cell fate. We found that Id2 deletion reduced the Tex-eff population, whereas Id3 ablation in CD4-Cre mice diminished Tpex cells, indicating subset-specific roles for Id2 and Id3. Mechanistically, E2A is a major target of Id2/3, and Runx3 interacts with E2A. Pulldown of Id2/3 recovered both E2A and Runx3, supporting an Id2/3?E2A?Runx3 regulatory complex. To map the genomic occupancy of Id2 and Id3, we expressed 3×T7-tagged Id2 or Id3 in in vitro-primed CD45.2+ P14 cells, adoptively transferred these cells into CD45.1 recipient mice, and infected the recipients with LCMV Clone 13. On day 6 post-infection, Tex-eff and Tpex cells were isolated for T7 CUT&RUN to define Id2 binding in Tex-eff cells and Id3 binding in Tpex cells, with the empty T7 vector backbone used as a negative control.

2026-04-20 | GSE310322 | GEO

Tumor infiltrating CD8+ Tex cells dictate divergent survival outcomes in pre- vs post-menopausal ER+ breast cancer

Project description:We identify subsets of BC tumors infiltrated by CD8+ T cells with characteristic features of exhausted T cells (TEX). Tumors with abundant CD8+ TEX exhibit a distinct tumor microenvironment marked by amplified interferon-γ signaling related pathways and higher PD-L1 expression.

2022-02-23 | GSE190169 | GEO

TEX cell fate and differentiation are shaped by 3D genome reorganization and chromatin architecture integrity [RNA-seq]

Project description:TEX cell fate and differentiation are shaped by 3D genome reorganization and chromatin architecture integrity [RNA-seq]

| PRJNA1151122 | ENA

TEX cell fate and differentiation are shaped by 3D genome reorganization and chromatin architecture integrity [CUT&RUN]

Project description:TEX cell fate and differentiation are shaped by 3D genome reorganization and chromatin architecture integrity [CUT&RUN]

| PRJNA1151123 | ENA

TEX cell fate and differentiation are shaped by 3D genome reorganization and chromatin architecture integrity [Hi-C]

Project description:TEX cell fate and differentiation are shaped by 3D genome reorganization and chromatin architecture integrity [Hi-C]

| PRJNA1151125 | ENA

TEX cell fate and differentiation are shaped by 3D genome reorganization and chromatin architecture integrity [ATAC-seq]

Project description:TEX cell fate and differentiation are shaped by 3D genome reorganization and chromatin architecture integrity [ATAC-seq]