Hypoxia induced alternative splicing transcript DGKG Δ exon13 promotes glioblastoma progression

ABSTRACT: Glioblastoma (GBM) is one of the most malignant types of central nervous system tumors. Oxygen deprivation in the tumor microenvironment is thought to be an important factor in promoting GBM progression. We found that new transcript DGKG Δ exon13 was generated in GBM under hypoxia via alternative splicing. Moreover, the results of CCK8, Transwell and Matrigel-transwell experiments showed that the proliferation, migration and invasion abilities of U87-MG and T98G were decreased after DGKG knockdown. Compared to wild-type DGKG, DGKG Δexon13 overexpressing significantly promoted cellular proliferation, migration and invasion abilities in GBM.

ORGANISM(S): Homo sapiens

PROVIDER: GSE275660 | GEO | 2026/08/20

REPOSITORIES: GEO