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SnRNA sequencing on the wat tissue of cecal ligation and puncture (CLP) and Sham mice.

ABSTRACT: Sepsis is a life-threatening condition that often leads to multi-organ dysfunction and energy dysruption. To explore the cellular response of the mouse wat during sepsis, we employed snRNA sequencing to profile differentially expressed genes (DEGs) across various wat cell types.

ORGANISM(S): Mus musculus

PROVIDER: GSE275740 | GEO | 2025/05/26

REPOSITORIES: GEO

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snRNA sequencing on the liver tissue of cecal ligation and puncture (CLP) and sham mice

Project description:Sepsis is a life-threatening condition that often leads to multi-organ dysfunction and energy dysruption. To explore the cellular response of the mouse liver during sepsis, we employed snRNA sequencing to profile differentially expressed genes (DEGs) across various liver cell types.

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snRNA sequencing on the kidney tissue of cecal ligation and puncture (CLP) and Sham mice.

Project description:Sepsis is a life-threatening condition that often leads to multi-organ dysfunction and energy dysruption. To explore the cellular response of the mouse kidney during sepsis, we employed snRNA sequencing to profile differentially expressed genes (DEGs) across various kidney cell types.

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Transcriptomic Profiling on Kidneys of Mice after Cecal Ligation and Puncture (CLP) Compared to Sham Operation

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snRNA sequencing on the wat tissue of cecal ligation and puncture (CLP) and Sham mice.

Project description:snRNA sequencing on the wat tissue of cecal ligation and puncture (CLP) and Sham mice.

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Impact of cecal ligation and puncture (CLP) on splenic NK1.1+CD3- gene expression [RNA-seq]

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Profiling circulating microRNA expression in experimental sepsis by cecal ligation and puncture

Project description:To profile the expression of circulating microRNAs (miRNAs) of mice in experimental sepsis by cecal ligation and puncture (CLP), the whole blood samples were obtained from C57BL/6 mice at 4, 8, and 24 h following CLP for miRNA expression analysis using a miRNA array (The Mouse & Rat miRNA OneArray® v3). Briefly, mice were anesthetized with a combination of ketamine and xylazine as the anesthetic/analgesic agents and a midline abdominal incision was made. The cecum was mobilized, ligated in the middle of cecum below the ileocecal valve, punctured once with a 21 G needle, and a little stool was squeeze out of the cecum to induce polymicrobial peritonitis. The abdominal wall was closed in two layers. Sham-operated mice underwent the same procedure, including opening the peritoneum and exposing the bowel, but without ligation and needle perforation of the cecum.

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Profiling circulating microRNA expression in experimental sepsis by cecal ligation and puncture

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Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture

Project description:Antimicrobial peptides possess a myriad of molecular properties including bacterial killing and the regulation of many aspects of innate immunity. Cathelicidins are a group of antimicrobial peptides widely investigated by the scientific community. Many studies have focused on the bactericidal and pro-inflammatory roles of cathelicidins. Because the role of endogenous cathelicidin expression remains obscure in deep-seated systemic infections, we induced sepsis in cathelicidin knockout and wild-type (WT) mice by cecal ligation and puncture, performing transcriptome screening by DNA microarray in conjunction with other immunologic assays. Cathelicidin-deficient mice showed increased survival compared to WT mice in this established experimental model of polymicrobial sepsis, in association with upregulation of certain key inflammatory response genes. Therefore, cathelicidins can exert both pro- and anti-inflammatory activities depending on the disease and cellular context.

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