Effect of propranolol on murine B16F10 metastasis-bearing lungs or on monocytes isolated from these lungs

ABSTRACT: We demonstrate that the β-blocker propranolol strongly reduces lung metastasis in multiple murine models, with the reduction being completely dependent on CD4+ T cells. To dissect the underlying mechanisms behind the anti-metastatic effect of propranolol, an experimental B16F10 lung metastasis model was combined with propranolol treatment. Total lung RNA or RNA from FACS-isolated lung monocytes and magnetic bead-isolated CD4+ T-cells were subjected to RNA sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE275763 | GEO | 2025/09/17

REPOSITORIES: GEO