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Gene expression profile of Cd45 positive cells in single cell level from KRASLSL.G12D/+P53LSL.R172H/+Pdx-Cre mice (KPC tumor mouse) model treated with stimulator of interferon genes (STING) and lymphotoxin-beta receptor (LTbR) agonist

ABSTRACT: The combination treatment using STING and LTbR agonists improves the immune landscape in KPC tumor model. We used single-cell RNA sequence (scRNAseq) analysis to investigate the characteristics of Cd45 positive cells after treating the tumor.

ORGANISM(S): Mus musculus

PROVIDER: GSE275840 | GEO | 2025/07/22

REPOSITORIES: GEO

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Gene expression profile of Cd45 positive cells in single cell level from KRASLSL.G12D/+P53LSL.R172H/+Pdx-Cre mice (KPC tumor mouse) model treated with stimulator of interferon genes (STING) and lymphotoxin-beta receptor (LTbR) agonist [2024_v2]

Project description:The combination treatment using STING and LTbR agonists improves the immune landscape in KPC tumor model. We used single-cell RNA sequence (scRNAseq) analysis to investigate the characteristics of Cd45 positive cells after treating the tumor.

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Project description:Gene expression profile of Cd45 positive cells in single cell level from KRASLSL.G12D/+P53LSL.R172H/+Pdx-Cre mice (KPC tumor mouse) model treated with stimulator of interferon genes (STING) and lymphotoxin-beta receptor (LTbR) agonist

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Comprehensive understanding the molecular components of LTBR signalling complex in cancers

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LTBR-mediated immunomodulation of the tumor microenvironment promotes anti-tumor responses

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Transcriptome profiling of spleen and duodenum upon lymphotoxin beta receptor (LTbR) induction

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Developmental LTbR synergistically activates TLR4 mediated inflammatory RelA/NF-kB response

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2025-03-26 | PXD061967 | Pride

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