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H4K16 acylations fine-tune transcriptional response during metabolic perturbations (ChIP-seq)

ABSTRACT: We studied the combined effects of the H4K16 acylations in vivo using a mouse model of the metabolic disorder propionic acidemia (PA), which causes metabolic challenges and systemic shifts in acyl-CoA ratios. Our findings indicate that H4K16 acylations modulate transcriptional responses in a concerted manner, providing insights into an adaptive chromatin regulation in response to metabolic stress.

ORGANISM(S): Mus musculus

PROVIDER: GSE275933 | GEO | 2025/12/01

REPOSITORIES: GEO

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