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Erythroid ACKR1 deficiency aggravates immune-mediated kidney disease

ABSTRACT: Single nucleotide polymorphisms (SNP) of atypical chemokine receptor 1 (ACKR1) gene encode human Duffy Antigen blood groups. The majority of individuals of West African ancestry carry a SNP in the promoter region of the ACKR1 that disrupts its transcription in erythroid cells only, but not in venular endothelial cells, leading to an “erythroid silent”, FyBES Duffy phenotype.Irradiation bone marrow ACKR1 chimeric mice lacking erythroid ACKR1 (KO->WT) showed increased disease activity and fibrosis after induction of nephrotoxic serum nephritis (NTSN), as compared to their respective controls (WT->WT).

ORGANISM(S): Mus musculus

PROVIDER: GSE276017 | GEO | 2026/04/15

REPOSITORIES: GEO

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