Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profile at single cell level of mouse liver in whole and fibrotic niche of the liver

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE276072 | GEO | 2025/02/11

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Resolving the fibrotic niche of human liver cirrhosis at single-cell level.

Project description:Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better understanding of the cellular and molecular mechanisms involved in disease pathogenesis and enable the discovery of therapeutic targets, here we profile the transcriptomes of more than 100,000 single human cells, yielding molecular definitions for non-parenchymal cell types that are found in healthy and cirrhotic human liver. We identify a scar-associated TREM2+CD9+ subpopulation of macrophages, which expands in liver fibrosis, differentiates from circulating monocytes and is pro-fibrogenic. We also define ACKR1+ and PLVAP+ endothelial cells that expand in cirrhosis, are topographically restricted to the fibrotic niche and enhance the transmigration of leucocytes. Multi-lineage modelling of ligand and receptor interactions between the scar-associated macrophages, endothelial cells and PDGFRα+ collagen-producing mesenchymal cells reveals intra-scar activity of several pro-fibrogenic pathways including TNFRSF12A, PDGFR and NOTCH signalling. Our work dissects unanticipated aspects of the cellular and molecular basis of human organ fibrosis at a single-cell level, and provides a conceptual framework for the discovery of rational therapeutic targets in liver cirrhosis.

| S-EPMC6876711 | biostudies-literature

Gene expression profile at single cell level of mouse liver in whole and fibrotic niche of the liver [FiNi-seq]

Project description:Age-dependent fibrosis accumulated in the liver includes driver cell types of aging. We used single cell RNA sequencing (scRNA-seq) from specially digested liver to analyze the age-related fibrosis.

2025-02-15 | GSE289699 | GEO

Gene expression profile at single cell level of mouse liver in whole and fibrotic niche of the liver (ATAC-Seq)

2025-02-11 | GSE276067 | GEO

Gene expression profile at single cell level of mouse liver in whole and fibrotic niche of the liver (scRNA-Seq)

2025-02-11 | GSE276063 | GEO

Gene expression profile at single cell level of mouse liver in whole and fibrotic niche of the liver

Project description:Gene expression profile at single cell level of mouse liver in whole and fibrotic niche of the liver

| PRJNA1154634 | ENA

Gene expression profile at single cell level of mouse liver in whole and fibrotic niche of the liver [FiNi-seq]

Project description:Gene expression profile at single cell level of mouse liver in whole and fibrotic niche of the liver [FiNi-seq]

| PRJNA1224215 | ENA

Gene expression profile at single cell level of mouse liver in whole and fibrotic niche of the liver (ATAC-Seq)

Project description:Gene expression profile at single cell level of mouse liver in whole and fibrotic niche of the liver (ATAC-Seq)

| PRJNA1154637 | ENA

Gene expression profile at single cell level of mouse liver in whole and fibrotic niche of the liver (scRNA-Seq)

Project description:Gene expression profile at single cell level of mouse liver in whole and fibrotic niche of the liver (scRNA-Seq)

| PRJNA1154629 | ENA

Extracellular Matrix Proteome of Aging-Specific Fibrotic Niche Cells in Mouse Liver Tissue

Project description:The extracellular matrix (ECM) is a complex network comprising hundreds of proteins, serving not only a structural role in shaping multicellular organisms but also participating in signaling processes. Moreover, the ECM exhibits high tissue specificity and undergoes significant alterations with aging progression. We analyzed the proteome of ECM produced by liver aging-specific fibrotic niche cells in old mice to obtain an age-related proteome profile. Our analysis revealed the identification of 714 quantifiable proteins, with 126 classified as matrisome proteins according to the matrisome database. Notably, proteins significantly upregulated in the ECM of liver aging-specific fibrotic niche cells indicated characteristics reminiscent of ECM formation (Eln, Mfap4, Lox, Tgfb2, Thbs2) and immune cell recruitment (Cxcl12), akin to those originating from fibrotic regions. Our findings suggest that this study may contribute to elucidating heightened fibrotic characteristics associated with the aging process.

2025-02-13 | PXD060715 | Pride

Single molecule-level metabolic responsive landscape of human liver transcriptome

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-02-01 | GSE224281 | GEO