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Bulk RNA seq data for sorted human CD34+CD38low cells after DMSO or 78c treatment

ABSTRACT: Hematopoietic stem cells (HSCs) balance self-renewal and differentiation within the bone marrow, a process that is disrupted under in vitro conditions, posing challenges for ex vivo studies and clinical applications such as gene therapy. This study examines the role of CD38, a glycoprotein involved in NAD+ metabolism, in regulating HSC function. Inhibition of CD38 activity with the small molecule 78c significantly increased the percentage of phenotypic HSCs and maintained their engraftment potential in mice, akin to uncultured cells.Here we performed bulk RNA seq on DMSO and 78c treated human CD34+CD38low cells to look for the transcriptomic differences between the two groups.

ORGANISM(S): Homo sapiens

PROVIDER: GSE276288 | GEO | 2024/10/01

REPOSITORIES: GEO

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