Effect of p53 on the expression of combo induced dsRNAs in 2153L GEM tumors

ABSTRACT: We analyzed the expression of dsRNAs in control and p53 restored 2153L GEM tumors upon different treatments. Our ChIP-seq and RNA-seq experiments showed that the restored p53 bound to the regulatory regions of dsRNA-containing genes that account for 91% of the total dsRNA abundance in combination therapy–treated 2153L tumors, and suppressed their expression upon combination therapy. The abundance of dsRNA (TPM) was calculated from the dsRIP experiment.

ORGANISM(S): Mus musculus

PROVIDER: GSE276354 | GEO | 2024/10/16

REPOSITORIES: GEO