Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE276491 | GEO | 2025/06/10

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (HiChIP)

Project description:Epstein-Barr virus Nuclear Antigen Leader Protein (EBNA-LP) plays a pivotal role in the transformation of B cells by Epstein-Barr virus (EBV), functioning independently of EBNA2 to regulate chromatin architecture and gene expression. Our study reveals that EBNA-LP binds to chromatin regions distinct from EBNA2 and facilitates the formation of long-distance chromatin loops by interacting with the cellular factor YY1. This interaction reconfigures the three-dimensional structure of the host genome, enhancing the integrity of topologically associating domains (TADs) and promoting the interaction between enhancers and promoters within these domains. In EBV-infected B cells, EBNA-LP strengthens YY1-mediated chromatin loops within TADs, which helps maintain stable regulatory programs essential for B cell transformation. Notably, EBNA-LP is crucial for establishing EBV-induced enhancers, yet it is not required for their maintenance once formed. Additionally, our data suggest a compensatory increase in CTCF binding in the absence of EBNA-LP, leading to more promiscuous chromatin interactions between TADs and a reduced TAD insulation at their boundaries. These findings provide new insights into the molecular mechanisms by which EBNA-LP contributes to B cell transformation and highlight potential therapeutic targets for disrupting EBV-driven oncogenesis

2025-06-10 | GSE276488 | GEO

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (HiC)

2025-06-10 | GSE276487 | GEO

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (RNA-Seq)

2025-06-10 | GSE276489 | GEO

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (ATAC-seq)

2025-06-10 | GSE276484 | GEO

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (CUT&Run)

2025-06-10 | GSE276486 | GEO

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (ChIP-Seq)

2025-06-10 | GSE276485 | GEO

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus

Project description:EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus

| PRJNA1157452 | ENA

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (HiC)

Project description:EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (HiC)

| PRJNA1157455 | ENA

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (HiChIP)

Project description:EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (HiChIP)

| PRJNA1157460 | ENA

EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (RNA-Seq)

Project description:EBNA Leader Protein is required to reshape chromatin architecture during B cell transformation by Epstein-Barr Virus (RNA-Seq)

| PRJNA1157459 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data