Single cell RNA-sequencing of Lepr+ lung mesenchymal cells in normal and fibrotic mouse lungs

ABSTRACT: A hallmark of pulmonary fibrosis is aberrant activation of lung fibroblasts to become pathological fibroblasts producing excessive extracellular matrix (ECM). Here, we showed Lepr-CreERT2 lineage labels lung mesenchymal cells including the majority of alveolar fibroblasts, which signigicatly contribute to pathological fibroblasts in bleomycin induced lung fibrosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE276546 | GEO | 2024/11/25

REPOSITORIES: GEO