Effect of advanced glycation end products on endometrial receptivity in patients with polycystic ovary syndrome

ABSTRACT: The endometrium receptivity was impaired in polycystic ovarian syndrome (PCOS), which would then lead to many fertility issues. Elevated levels of advanced glycation end products (AGEs) have been observed in women with PCOS, which are produced endogenously or absorbed from modern hot-processed diets, and data from in vitro experiments, animal models, and human studies suggest that AGEs may be involved in the pathogenesis of PCOS and its metabolic and reproductive consequences. The purpose of this study was to investigate the accumulation of AGEs in in women and animal model with PCOS, and its effect on endometrial receptivity, and to explore the possible potential of AGEs receptor antagonist, N-Benzyl-N-cyclohexyl-4-chlorobenzamide (FPS-ZM1), in improving endometrial receptivity. In this study, Dehydroepiandrosterone (DHEA) was used to establish a PCOS rat model to explore the mechanism of AGEs affecting endometrial receptibility, and to explore the effectiveness of FPS-ZM1, in improving endometrial receptibility in PCOS rats. We here reported excessive accumulation of AGEs exists in the endometrium of both PCOS women and PCOS rats. After binding to its receptors, AGEs can increase inflammation and apoptosis levels, inhibit angiogenesis, reduce endometrial thickness and thus reduce endometrial receptivity by activating JNK and p38 MAPK pathways. FPS-ZM1 can improve endometrial receptivity in PCOS rats by inhibiting this pathway, thereby reducing inflammation and apoptosis levels, promoting angiogenesis and increasing endometrial thickness.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE276661 | GEO | 2026/09/01

REPOSITORIES: GEO