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T cell exhastion is programmed by dynamic 3D genome reorganization

ABSTRACT: CTCF is recognized for its role in facilitating long-range chromatin interactions and 3D genome organization. In CD8+ T cells responding to chronic infection, CTCF undergoes redistribution to activate the exhausted cytotoxic effector (Tex-eff) program while simultaneously utilizing its insulation function to regulate the fate of precursors to stem-like exhausted T (Tex-prec) cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE276723 | GEO | 2026/06/03

REPOSITORIES: GEO

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