RNA decay profile for eRF1 and UPF1 depletion in HCT116 cell lines

ABSTRACT: We had found that non-optimal codon induced frameshifting translation coupled with NMD may play a crucial role in maintaining delicate need of mRNA from yeast to human. Our data suggests that NCFT also exist in human. We constructed eRF1-KD and UPF1-KD cell line and resort α-amanitin to treat cells in different time point, then transcriptionally profiled them to get the landscape of mRNA stability.

ORGANISM(S): Homo sapiens

PROVIDER: GSE276918 | GEO | 2025/05/31

REPOSITORIES: GEO