Highly Pathogenic Avian Influenza Viruses Avoid Effective Inflammatory Response of Human Macrophages

ABSTRACT: Macrophages were infected with low (PR8) and high pathogenic influenza viruses (FPV and H5N1). To our surprise a genome-wide comparative systems biology approach revealed that in contrast PR8 infections with HPAIV H5N1 and FPV result in a reduced immune response of human macrophages contradicting a primary role of this cell type for the cytokine storm. Our data point to a viral strategy of HPAIV to bypass a major amplifier of the initial local inflammatory response thereby hampering antiviral effector mechanisms and facilitating virus spreading and systemic disease.

ORGANISM(S): Homo sapiens

PROVIDER: GSE27702 | GEO | 2012/05/29

SECONDARY ACCESSION(S): PRJNA138131

REPOSITORIES: GEO