Transcriptomics

Dataset Information

17

Signature of MicroRNAs with Impact on Angiogenesis in Non-Small Cell Lung Cancer


ABSTRACT: Angiogenesis is regarded as a hallmark in cancer development, and anti-angiogenic treatment is presently used in non-small cell lung cancer (NSCLC) patients. MicroRNAs (miRs) are small non-coding, endogenous, single stranded RNAs that regulate gene expression. As miRs are relatively stabile and measurable in both tissue and serum, they are potential prognostic and predictive markers. In this study we aimed to identify significant altered miRs related to angiogenesis in NSCLC Overall design: From a large cohort of 335 NSCLC patients, paraffin-embedded samples from 10 patients with a short disease specific survival (DSS), 10 with a long DSS and 10 normal controls were analyzed.

INSTRUMENT(S): miRCURY LNA microRNA Array, 5th generation - hsa, mmu & rno

ORGANISM(S): Homo sapiens  

SUBMITTER: Chris Fenton   

PROVIDER: GSE27705 | GEO |

SECONDARY ACCESSION(S): PRJNA138125

REPOSITORIES: GEO

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