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Microglial Gpr126 is essential for hippocampal developmental synapse remodeling and shapes adolescent behavior in mice

ABSTRACT: To comprehensively understand the complexity of the different cell types and transcriptional pathways involved in the microglia-synapse interaction following microglial GPR126 deletion, we performed single-cell RNA sequencing (scRNA-seq) on hippocampal samples harvested from 2-week-old mice, a time point with changes in synaptic density and transmission in Gpr126 cKO mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE277113 | GEO | 2026/09/30

REPOSITORIES: GEO

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