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An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia

ABSTRACT: Single-cell transcriptome analysis revealed an enrichment of Fos+ MPP subpopulations in mouse bone marrow under hypoxic conditions. To validate the biological characteristics and hypoxia stress response of the Fos+ MPP subpopulation, we used Fos-2A-tdTomato mice to establish a HAPC model. We then sorted Fos+ and Fos- MPP cells for low-input DNA methylation sequencing analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE277134 | GEO | 2025/05/29

REPOSITORIES: GEO

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An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia

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