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Single-nucleotide resolution m6A peak and their unqiue characteristics in developing mouse forebrain

ABSTRACT: We investigated the accurate location and methylation stochiometry for Mettl14-dependent m6A peaks in the samples from P0 mouse forebrains using m6A-SAC-seq. We found that m6A-modified transcripts showed strong enrichment for genes associated with synapse organization, axonogenesis, positive regulation of cell projection organization, and regulation of synapse, implying that m6A-modified RNAs play a key role in neuronal differentiation during early postnatal cortical development .

ORGANISM(S): Mus musculus

PROVIDER: GSE277229 | GEO | 2026/01/01

REPOSITORIES: GEO

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