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Genome-wide analysis of perinatal effect of nitric oxide (NO) donor molsidomine on the kidneys of Fawn-Hooded Hypertensive (FHH) rats at different ages

ABSTRACT: Microarray was performed on kidneys in molsidomine-treated FHH rats in order to gain understanding why perinatal treatment with molsidomine in FHH was beneficial in FHH offspring (e.g. lower blood pressure and less renal damage)

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE27725 | GEO | 2011/07/01

SECONDARY ACCESSION(S): PRJNA138099

REPOSITORIES: GEO

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Genome-wide analysis of perinatal effect of nitric oxide (NO) donor molsidomine on the kidneys of Fawn-Hooded Hypertensive (FHH) rats at different ages

Project description:Microarray was performed on kidneys in molsidomine-treated FHH rats in order to gain understanding why perinatal treatment with molsidomine in FHH was beneficial in FHH offspring (e.g. lower blood pressure and less renal damage) In total 62 samples were used. 6 different groups for each gender: 2d, 2w and adult rats with or without molsidomine treatment. Total 12 groups.

2011-06-30 | E-GEOD-27725 | biostudies-arrayexpress

Genome-wide analysis of perinatal effect of NF-kabbaB inhibition by pyrrolidine dithiocarbamate (PDTC) on the kidneys of Fawn-Hooded Hypertensive (FHH) rats at ages 2 days, 2 weeks and adult

Project description:Microarray was performed on kidneys of Fawn-Hooded Hypertensive (FHH) rats in order to elucidate the so-called "beneficial" effect of perinatal treatment with PDTC.

2014-06-15 | GSE57066 | GEO

Genome-wide analysis of perinatal effect of NF-kabbaB inhibition by pyrrolidine dithiocarbamate (PDTC) on the kidneys of Fawn-Hooded Hypertensive (FHH) rats at ages 2 days, 2 weeks and adult

Project description:Microarray was performed on kidneys of Fawn-Hooded Hypertensive (FHH) rats in order to elucidate the so-called "beneficial" effect of perinatal treatment with PDTC. In total, 59 samples were used. At least 4 rats per treatment groups. 2d, 2w and adult rats with or without PDTC treatment. Total 12 groups.

2014-06-15 | E-GEOD-57066 | biostudies-arrayexpress

Cadaveric vs. live donor kidneys

Project description:Recipients of live donor transplant kidneys (LIV) exhibit a significantly longer allograft half-life compared with cadaveric donor organs (CADs). The reasons are incompletely understood. Therefore this study sought to elucidate the genome-wide gene expression profiles in microdissected transplant kidney biopsies obtained from five cadaveric and five matched live donors before transplantation. cDNA microarrays were used to determine the transcripts in isolated glomeruli (G) and the tubulointerstitial (TI) compartment. Data were subjected to hierarchical clustering, maxT adjustment and a jackknife procedure to ensure robustness of reported findings; validation was performed by independent analysis of split biopsies and TaqMan-PCR. One hundred and thirteen sequences representing 62 unique genes (17 redundant features), and 34 ESTs separated G from TI. No difference in gene expression was found in G between LIV and CAD kidneys, but nine genes (two represented twice) and three ESTs were abundantly expressed in the CAD TI compared with LIV. The main biological function of these genes is counter regulation of oxidative stress. Promoter analysis of significant features suggested coregulated gene groups. These data suggest that CAD kidneys exhibit a distinctly different set of transcripts in the TI compartment but not in the G compartment when compared with LIV kidneys. An all pairs experiment design type is where all labeled extracts are compared to every other labeled extract. Computed

2006-01-11 | E-GEOD-4018 | biostudies-arrayexpress

Cadaveric vs. live donor kidneys

2006-01-12 | GSE4018 | GEO

Perinatal exogenous nitric oxide in fawn-hooded hypertensive rats reduces renal ribosomal biogenesis in early life.

Project description: Not available

| S-EPMC3268605 | biostudies-literature

Effect of perinatal obesity on premature kidney aging signaling

Project description:Chronic Kidney Disease (CKD), a global health burden, is strongly associated with age-related renal function decline, hypertension and diabetes, frequent consequences of obesity. Despite extensive studies the mechanisms determining susceptibility to CKD remain elusive. Clinical evidence together with prior studies from our group showed that perinatal metabolic disorders after maternal obesity adversely affect kidney structure and function throughout life. Since obesity and aging processes converge in similar pathways we tested if perinatal obesity induced by High-Fat Diet (HFD)-fed female mice sensitizes aging-associated mechanism in kidneys of newborn mice. Tissue from the kidney cortex and the kidney medulla was collected from offspring of control or HFD-fed mice.

2022-12-31 | E-MTAB-10954 | biostudies-arrayexpress

Laparoscopic Donor Nephrectomy Gene Expression Profiling Compared to Healthy Control Kidneys

Project description:We compared gene expression profiles from six donor kidneys prior to surgical manipulation to six kidneys removed after laparoscopic donor nephrectomy (LDN) and several hours of CO2 pneumoperitoneum. Biopsies were obtained from renal cortex and hybridized to Affymetrix HG-U133A GeneChips. For control kidneys we identified 1380 genes present on all 6 samples that had a signal intensity greater than 1000. Functional classification of these revealed genes for cellular signaling (201; 15%), regulation of transcription (156; 11%), cellular transport (144; 10%) and cellular metabolism (111; 8%). A class comparison between the controls and LDN kidneys yielded 865 differentially expressed genes. Functional classification of the 502 genes differentially up-regulated in LDN kidneys identified associations with apoptosis, cell adhesion, cell signaling, regulation of cell growth/proliferation, immune/inflammation, ischemia/stress response and proteolysis/peptidolysis. These data demonstrate an altered renal transcriptome induced by several hours of CO2 pneumoperitoneum and laparoscopic surgery characterized by up-regulation of ischemia and injury associated genes. Keywords: Comparative Expression

2005-09-14 | GSE3297 | GEO

Recent developments in nitric oxide donor drugs.

Project description: Not available

| S-EPMC2013979 | biostudies-other

Brain death associated activation of Calpain-Talin axis in donor kidneys underlies podocyte matrix degradation and graft dysfunction in kidney transplantation

Project description:Deceased kidney donation after brain death (DBD) is the main source of transplants, yet these grafts yield inferior transplant outcomes when compared to living donation. In brain death, cerebral injury contributes to systemic biological dysregulation, causing significant cellular stress in donor kidneys that adversely impacts the quality of grafts. Here, we hypothesized that proteolytic processes in DBD kidneys might lead to podocyte damage with subsequent development of post-transplant dysfunction. Using protein topography and migration analysis platform (PROTOMAP), we mapped degradation profiles of cytoskeletal proteins in DBD kidneys. Cytoskeletal proteolytic degradation was further studied by Immunoblotting on a separate cohort of deceased and living donor kidney biopsies. To investigate potential mechanism of kidney cytoskeletal protein degradation, in-vitro human podocytes and ex-vivo precision-cut human kidney slices were employed. We found novel proteolytic profiles of key podocyte cytoskeletal proteins in donor kidneys associated with suboptimal posttransplant function. These were unique to brain-death and were not observed in circulatory-death or living-donor kidneys. Talin-specific protein degradation in DBD kidneys indicated Calpain-1 activation may have a key role in proteolytic processes observed in the dysfunctional kidneys. Investigation of the underlying mechanism suggests that Transforming-Growth Factor-Î² (TGFÎ²) induces Calpain-1 activation, leading to brain-death specific podocyte degradation patterns and dysregulation of actin cytoskeleton; events that were prevented, in-vitro, by Calpain inhibition. Conclusion Our data demonstrate that podocyte protein degradation impacts the quality of DBD kidneys, propose a role of TGFÎ² mediated Calpain-1 proteolytic processing of cytoskeletal Talin-1, suggesting therapeutic opportunities to prevent kidney dysfunction.

2022-08-12 | PXD022074 | Pride

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