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The Effect of Methyl Donors in a Murine Model of MASLD in a Multidisciplinary Study.

ABSTRACT: Addressing the challenge of Metabolic Dysfunction Associated Steatotic Liver Diseases (MASLD), this study assesses the efficacy of methyl donor supplementation in a C57BL/6J mouse model, hypothesizing its potential to mitigate disease symptoms through epigenetic and metabolic pathways. In the liver, global DNA methylation was quantified and the transcriptome was analyzed using dual-channel microarrays. An increased DNA methylation, normalization in the expression of lipid-related genes, and hypermethylation of lipogenic genes were observed in methyl donnors supplemental mice (MET).

ORGANISM(S): Mus musculus

PROVIDER: GSE277537 | GEO | 2025/09/23

REPOSITORIES: GEO

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