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Gpnmb⁺ Microglia Represent a Distinct Subtype Reacting to Neuronal Loss induced by Prion Disease

ABSTRACT: Of all neurodegenerative pathologies, prion diseases exhibit one of the most extensive neuroinflammatory phenotypes, yet the impact of neuroinflammation on the course of the disease is anything but clear . Prions trigger conspicuous proliferation of microglial cells, which may contribute to neuronal damage but are also involved in prion clearance . We approached these questions by establishing a spatial-transcriptomic atlas of the progression of prion disease, and identified GPNMB gene as the most enriched one in a subset of microglial cells with enhanced phagocytic activity present only in prion-infected mice. This cell type responded to ongoing apoptosis in distinct brain regions from 30 weeks post-prion inoculation and progressively increased up to the terminal stage of the disease.

ORGANISM(S): Mus musculus

PROVIDER: GSE277577 | GEO | 2025/09/19

REPOSITORIES: GEO

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Gpnmb⁺ Microglia Represent a Distinct Subtype Reacting to Neuronal Loss induced by Prion Disease

Project description:Gpnmb⁺ Microglia Represent a Distinct Subtype Reacting to Neuronal Loss induced by Prion Disease

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