AgRP neurons shape the sperm small RNA payload

ABSTRACT: Dietary habits and obesity in fathers imprint upon progeny through epigenetic signals carried by sperm RNA. By activating hypothalamic AgRP neurons in mice to mimic obesity's effects, we observed significant alterations in sperm tsRNAs, miRNAs, and rsRNAs. These changes, particularly in tsRNAs, mirror those seen with short-term high-fat diets, suggesting a shared upstream regulatory mechanism involving AgRP neurons that influence metabolic epigenetic inheritance.

ORGANISM(S): Mus musculus

PROVIDER: GSE277621 | GEO | 2024/10/22

REPOSITORIES: GEO