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Melanoma derrived Short Term Cultures characterization to identify Potential targets in NF1 mutant melanoma [NF1 knockdown CUT&RUN]

ABSTRACT: The Neurofibromin 1 (NF1) tumor suppressor gene is mutated in 15-27% of melanoma patients. The overall prognosis of these patients is worse than that of patients with other genetic melanoma subtypes due to a paucity in targeted therapy options for this melanoma subtype, and its limited response to immunotherapy. Here, we compare NF1 mutant to NF1 wild melanoma using a combined multi-omics approaches of patient-derived short-term cultures (STCs) to identify potential therapeutic targets

ORGANISM(S): Homo sapiens

PROVIDER: GSE277804 | GEO | 2025/05/09

REPOSITORIES: GEO

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