Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Regulation of the NSL complex by TAF4A is critical for genome stability and quiescence of skeletal muscle stem cells.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE277872 | GEO | 2025/08/29

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Regulation of the NSL complex by TAF4A is critical for genome stability and quiescence of skeletal muscle stem cells

Project description:Acetylation of lamin A/C by the NSL complex, containing MOF and KANSL2, is instrumental for maintaining nuclear architecture and genome stability, but the mechanisms controlling expression of NSL complex components in different cell types are poorly characterized. Here, we describe that TAF4A, primarily known as a subunit of the general transcription factor TFIID, is critical for cell type-specific regulation of Kansl2 in MuSCs. Inactivation of Taf4a in MuSCs reduces expression of Kansl2 and alters post-translational modification of lamin A/C, thereby decreasing the stiffness of MuSC nuclei and disrupting the nuclear architecture. Using CUT&RUN technique, we found that TAF4A together with the heterotrimeric transcription factor NF-Y controls Kansl2 expression. In addition to destabilization of the nuclear architecture, reduced expression of Kansl2 in Taf4a-mutant MuSCs changes expression of numerous genes involved in chromatin regulation. The subsequent loss of heterochromatin and MuSC activation, in combination with pronounced genomic instability, activates MuSCs and impairs MuSC proliferation, which depletes the stem cell pool and abolishes skeletal muscle regeneration. We conclude that TAF4A-NF-Y-dependent transcription regulation safeguards heterochromatin and genome stability of MuSCs via the NSL complex.

2025-09-02 | GSE299832 | GEO

Regulation of the NSL complex by TAF4A is critical for genome stability and quiescence of skeletal muscle stem cells [CnR of TAF4A in WT MuSCs]

2025-09-02 | GSE277867 | GEO

Regulation of the NSL complex by TAF4A is critical for genome stability and quiescence of skeletal muscle stem cells [CnR of KANSL2 in WT MuSCs]

2025-09-02 | GSE277868 | GEO

Regulation of the NSL complex by TAF4A is critical for genome stability and quiescence of skeletal muscle stem cells [CnR of NF-YA in WT MuSCs]

2025-09-02 | GSE277869 | GEO

Regulation of the NSL complex by TAF4A is critical for genome stability and quiescence of skeletal muscle stem cells [RNA-seq of MuSCs from control and Taf4asKOmice]

2025-09-02 | GSE277871 | GEO

Regulation of the NSL complex by TAF4A is critical for genome stability and quiescence of skeletal muscle stem cells [CnR of NF-YA in WT and Taf4asKO MuSCs]

2025-09-02 | GSE277870 | GEO

Regulation of the NSL complex by TAF4A is critical for genome stability and quiescence of skeletal muscle stem cells.

Project description:Regulation of the NSL complex by TAF4A is critical for genome stability and quiescence of skeletal muscle stem cells.

| PRJNA1164672 | ENA

Regulation of the NSL complex by TAF4A is critical for genome stability and quiescence of skeletal muscle stem cells

Project description:Regulation of the NSL complex by TAF4A is critical for genome stability and quiescence of skeletal muscle stem cells

| PRJNA1276591 | ENA

Regulation of the NSL complex by TAF4A is critical for genome stability and quiescence of skeletal muscle stem cells [CnR of TAF4A in WT MuSCs]

Project description:Regulation of the NSL complex by TAF4A is critical for genome stability and quiescence of skeletal muscle stem cells [CnR of TAF4A in WT MuSCs]

| PRJNA1164680 | ENA

Regulation of the NSL complex by TAF4A is critical for genome stability and quiescence of skeletal muscle stem cells [CnR of KANSL2 in WT MuSCs]

Project description:Regulation of the NSL complex by TAF4A is critical for genome stability and quiescence of skeletal muscle stem cells [CnR of KANSL2 in WT MuSCs]

| PRJNA1164679 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data