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The effect of leptin on the genome wide enrichment of cJun in OVCAR8 cells

ABSTRACT: Studies have shown that leptin activates several signaling pathways and stimulates the expression of numerous downstream genes and that the key transcription factor that exerts this effect might serve as a promising therapeutic target in leptin-driven ovarian cancer. cJun is a widely recognized transcription factor that is located downstream of MAPK signaling pathways, and encodes a nuclear protein that regulates various aspects of cell growth and differentiation. c-Jun is activated by JNK through phosphorylation at Ser63, Ser73, Thr91, and Thr93, and by ERK and p38 via increased gene expression. However, whether c-Jun is involved in leptin-mediated stemness maintenance in ovarian cancer remains mostly unknown.

ORGANISM(S): Homo sapiens

PROVIDER: GSE277884 | GEO | 2025/10/01

REPOSITORIES: GEO

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Transcriptome analysis of leptin on OVCAR8 cells

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The effect of leptin on the genome wide enrichment of cJun in OVCAR8 cells

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