Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Profiling non-human primate exosomal RNA to understand the legacy of early life stress

ABSTRACT: Motivated to identify novel molecular pathways and processes that are enduringly perturbed as a consequence of childhood maltreatment, we isolated circulating extracellular vesicles (EVs) from plasma collected from adolescent rhesus macaques. RNA sequencing revealed that macaque plasma EVs contain RNA aligned to the microbiome.

ORGANISM(S): Macaca mulatta

PROVIDER: GSE277948 | GEO | 2025/09/28

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Profiling mouse exosomal RNA to understand antibiotics treatment consequences

Project description:We isolated circulating extracellular vesicles (EVs) from plasma collected from adolescent mus musculus. RNA sequencing revealed that mouse plasma EVs contain RNA aligned to the microbiome.

2025-07-24 | GSE302894 | GEO

Profiling non-human primate exosomal RNA to understand the legacy of early life stress

Project description:Validation of the etection of the RNA content in plasma exosomes of rhesus macaques.

2023-02-20 | GSE223984 | GEO

Profiling nonhuman primate germline RNA to understand the legacy of early life stress.

Project description:Exposure to stress is a risk factor for perturbed mental health, including impoverished regulation of emotional and physiological responses that accompany anxiety and mood disorders, substance abuse and behavioral disorders. Such disruptions to well-being could be triggered by discrete environmental events or pervasive early life stress (ELS) resulting for example from adverse caregiving. Recent data mostly collected from rodents exposed to anthropogenic stressors suggest that one way via which the detrimental effects of such stress extend beyond the exposed population to future offspring is via stress-induced alterations of RNA found in the paternal germline. In contrast, less attention has been paid to how naturally occurring stress in males might influence offspring biology and behavior. In this study, we used a translational nonhuman primate model of ELS caused by naturally occurring adverse caregiving of infant macaques to (1) profile total RNA in the adolescent male germline, and (2) identify how those RNA profiles are affected by exposure to ELS. Our findings that the top 100 transcripts identified correspond to transcripts related to germline biology and reproduction demonstrate the validity and feasibility of profiling RNA in the germline of rhesus macaques. While our small sample sizes precluded definitive assessment of stress-induced alterations of RNA in the male germline of rhesus macaques that experienced ELS, our study sets the foundation for future investigations of how early adversity might alter the male germline, across species and in experimental protocols that involve anthropogenic vs natural stressors.

| S-EPMC8671153 | biostudies-literature

Exosomal miRNA differences in Plasma in Adolescent idiopathic scoliosis patients

Project description:Plasma exosomal miRNA may differ between adolescent idiopathic scoliosis patients and healthy individuals. Sequencing analysis was used to find these differential miRNAs.

2024-05-15 | GSE235203 | GEO

Profiling non-human primate germline RNA to understand the legacy of early life stress

Project description:Validation of the methodology for extracting and demonstrating the quality of the ability to profile RNA in sperm of rhesus macaques.

2021-03-17 | GSE168978 | GEO

Profiling non-human primate exosomal RNA to understand the legacy of early life stress

Project description:Profiling non-human primate exosomal RNA to understand the legacy of early life stress

| PRJNA1164792 | ENA

Profiling non-human primate exosomal RNA to understand the legacy of early life stress

Project description:Profiling non-human primate exosomal RNA to understand the legacy of early life stress

| PRJNA929263 | ENA

Primate

Project description:Human, Chimpanzee, Gorilla, Orangutan, Macaque Epigenomics

| PRJNA563344 | ENA

Exosomal miRNA differences in Plasma in Adolescent idiopathic scoliosis patients

Project description:Exosomal miRNA differences in Plasma in Adolescent idiopathic scoliosis patients