Transcriptomic analysis of NAFLD model cells with the co-administration of pseudo-natural flavonol and copper

ABSTRACT: Copper deficiency is closely associated with non-alcoholic fatty liver disease (NAFLD). We developed pseudo-natural flavonol (HQF) as novel ionophore for rapid intracellular copper delivery. The co-administration of HQF and copper has synergistic effects in restraining lipid droplet formation with unknown mechanism. Here, hepatic HepG2 cells were treated with palmitic acid (PA) to construct a NAFLD cell model, which was used to investigate the biological effects of HQF-mediated copper delivery on NAFLD intervention.

ORGANISM(S): Homo sapiens

PROVIDER: GSE278008 | GEO | 2024/12/31

REPOSITORIES: GEO