PP2A attenuates thoracic aneurysm and dissection in mouse models of Marfan syndrome [RNA-seq]

ABSTRACT: Recent studies show that hyperactivation of mTOR signaling plays a causal role in the development of thoracic aortic aneurysm (TAA) and dissection (AAD). Modulation of Protein phosphatase 2A (PP2A) activity has been shown to be of significant therapeutic value. In light of the effects that PP2A can exert on mTOR pathway, we hypothesized that PP2A activation by small molecule activators of PP2A (SMAPs) could mitigate AA progression in Marfan Syndrome (MFS).

ORGANISM(S): Mus musculus

PROVIDER: GSE278185 | GEO | 2025/03/26

REPOSITORIES: GEO