Genomics,Multiomics

Dataset Information

27

Reprogramming Transcriptional Responses through Functionally-Distinct Classes of Enhancers in Prostate Cancer Cells


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

OTHER RELATED OMICS DATASETS IN: PRJNA141877PRJNA137903E-GEOD-27823PRJNA141903

INSTRUMENT(S): Illumina human-6 v2.0 expression beadchip

SUBMITTER: Christopher Benner  

PROVIDER: GSE27824 | GEO | 2011-05-15

SECONDARY ACCESSION(S): GSE27823 GSE27682PRJNA137903

REPOSITORIES: GEO

Dataset's files

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Publications


Mammalian genomes are populated with thousands of transcriptional enhancers that orchestrate cell-type-specific gene expression programs, but how those enhancers are exploited to institute alternative, signal-dependent transcriptional responses remains poorly understood. Here we present evidence that cell-lineage-specific factors, such as FoxA1, can simultaneously facilitate and restrict key regulated transcription factors, exemplified by the androgen receptor (AR), to act on structurally and fu  ...[more]

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