Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA141877PRJNA137903E-GEOD-27823PRJNA141903
INSTRUMENT(S): Illumina human-6 v2.0 expression beadchip
SUBMITTER: Christopher Benner
PROVIDER: GSE27824 | GEO | 2011-05-15
SECONDARY ACCESSION(S): GSE27823 GSE27682PRJNA137903
REPOSITORIES: GEO
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Wang Dong D Garcia-Bassets Ivan I Benner Chris C Li Wenbo W Su Xue X Zhou Yiming Y Qiu Jinsong J Liu Wen W Kaikkonen Minna U MU Ohgi Kenneth A KA Glass Christopher K CK Rosenfeld Michael G MG Fu Xiang-Dong XD
Nature 20110515 7351
Mammalian genomes are populated with thousands of transcriptional enhancers that orchestrate cell-type-specific gene expression programs, but how those enhancers are exploited to institute alternative, signal-dependent transcriptional responses remains poorly understood. Here we present evidence that cell-lineage-specific factors, such as FoxA1, can simultaneously facilitate and restrict key regulated transcription factors, exemplified by the androgen receptor (AR), to act on structurally and fu ...[more]