IRE1alpha cancer mutants diiferentially regulate Rho family GTPases

ABSTRACT: IRE1alpha is a multi-domain, ER-transmembrane protein that can mediate the Unfolded Protein Response (UPR). Here, we show that cancer-specific mutations in IRE1alpha can differentially activate the Rho family GTPases to mediate tumor promoting events in mouse keratinocytes.

ORGANISM(S): Mus musculus

PROVIDER: GSE278307 | GEO | 2025/08/06

REPOSITORIES: GEO