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An siRMSD parameter of structural distortion induced by chemical modification is predictive of the off-target effect of siRNA_(1/2)

ABSTRACT: To investigate effects of siRNA with various 2'-ribose modifications on genome-wide off-target effect, we analyzed gene expression profile of HeLa cells transfected by their siRNAs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE278438 | GEO | 2025/09/16

REPOSITORIES: GEO

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An siRMSD parameter of structural distortion induced by chemical modification is predictive of the off-target effect of siRNA_(2/2)

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