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Systems biology mapping of rBCG-LTAK63-induced protection against tuberculosis reveals the significance of autophagy and circadian rhythm regulation by cAMP

ABSTRACT: Using systems biology and RNA sequencing data from lung cells, we investigated the immune mechanisms of protection induced by this vaccine in mice, both after immunization and following challenge. The RNA-seq data were analyzed using IPA (Ingenuity Pathways Analysis), CEMiTools (modular co-expression analysis). The RNA-seq derived results were analysed through correlation with immune response and disease outcomes, such as bacillary load, pathology score (infiltrated cell number, inflammatory area, and functional area).

ORGANISM(S): Mus musculus

PROVIDER: GSE278523 | GEO | 2025/09/01

REPOSITORIES: GEO

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