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Effect of the rhesus theta defensin-1 (RTD-1) on gene expression in human monocytes. [II]

ABSTRACT: Rhesus theta defensin (RTD)-1, a cyclic antimicrobial peptide, regulates gene expression and immune signaling pathways in cell culture and animal models of immune mediated diseases. To gain insights into RTD-1 regulation of naïve cells, we performed RNA sequencing (RNA-seq) to determine the effect of RTD-1 on global gene expression in human monocytes. Analysis of differentially expressed genes revealed RTD-1 mediated stimulation of interferon and antiviral gene expression pathways in human monocytes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE278568 | GEO | 2025/12/09

REPOSITORIES: GEO

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Effect of the rhesus theta defensin-1 (RTD-1) on gene expression in human monocytic THP-1 cells. [I]

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