DNA methylation changes during prostate cancer lineage transitions

ABSTRACT: Conversion to a neuroendocrine phenotype is a known resistance mechanism to androgen receptor-directed therapies in prostate cancer. In this study, we analyze DNA methylation changes associated with neuroendocrine transdifferentiation using a patient-derived xenograft model that recapitulates these lineage transitions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE278588 | GEO | 2025/09/22

REPOSITORIES: GEO