Transcription profile of B cells isolated from peripheral lymph nodes of wild-type vs CCR7-/- mice

ABSTRACT: We investigated the transcriptional profile of B cells isolated from peripheral lymph nodes of CCR7-/-C57BL/6 and C57BL/6 mice respectively. B cells were sorted as follows: CD19+, CD3-, CD11c-, CD11b-, NK1.1-, GR-1-. Very few genes were differentially regulated in CCR7-/- B cells, however the expression of a number of genes associated with B-cell activation was increased in CCR7-/- B cells compared to WT B cells. Our data suggest a role of CCR7 signaling in B-cell activation processes.

ORGANISM(S): Mus musculus

PROVIDER: GSE27885 | GEO | 2011/11/21

SECONDARY ACCESSION(S): PRJNA137997

REPOSITORIES: GEO