Gene expression changes induced by HA-PRCC-TFE3 in HK-2 cells

ABSTRACT: PRCC-TFE3 is an oncogenic chimeric transcription factor identified in human TFE3-rearranged renal cell carcinoma. To analyze gene expression changes driven by PRCC-TFE3, we generated and utilized an HA-tagged PRCC-TFE3-inducible HK-2 cell line, which expresses HA-tagged PRCC-TFE3 in a doxycycline-dependent manner. Cells were cultured with or without doxycycline, and comprehensive gene expression analysis was conducted using RNA-seq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE278984 | GEO | 2025/01/07

REPOSITORIES: GEO