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MiRNA Profiles of Long-Lived Individuals (>=90 years)

ABSTRACT: This project analyzes peripheral blood profiles of patients of age 90 or above and aims to detect profiles that distinguish them from younger controls.

ORGANISM(S): Homo sapiens

PROVIDER: GSE27905 | GEO | 2013/01/01

SECONDARY ACCESSION(S): PRJNA138219

REPOSITORIES: GEO

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miRNA Profiles of Long-Lived Individuals (>=90 years)

Project description:This project analyzes peripheral blood profiles of patients of age 90 or above and aims to detect profiles that distinguish them from younger controls. n = 55 normal controls and n = 15 long lived individuals have been screened for the complete miRNA repertoire. Please note that each miRNA has been measured in seven replicates and the median of the replica has been computed.

2013-01-01 | E-GEOD-27905 | biostudies-arrayexpress

Expression of miRNAs in breast tumor from very youn women (<36) and women above 65 years old

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2014-09-12 | E-GEOD-48088 | biostudies-arrayexpress

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Gut microbiota may underlie the predisposition of healthy individuals to COVID-19

Project description:The COVID-19 pandemic is spreading globally with high disparity in the susceptibility of the disease severity. Identification of the key underlying factors for this disparity is highly warranted. Here we describe constructing a proteomic risk score based on 20 blood proteomic biomarkers which predict the progression to severe COVID-19. We demonstrate that in our own cohort without infection, this proteomic risk score is positively associated with proinflammatory cytokines mainly among older, but not younger, individuals. We further discovered that a core set of gut microbiota could accurately predict the above proteomic biomarkers using a machine learning model, and that these gut microbiota features are highly correlated with proinflammatory cytokines.

2020-06-09 | PXD019675 | iProX

Expression of miRNAs in breast tumor from very youn women (<36) and women above 65 years old

2014-09-12 | GSE48088 | GEO

SmallRNAseq analysis of the human retina miRNome of 16 individuals

Project description:This experiment analyzes the mirnome of 16 retina samples and 2 Retinal Pigment Epithelium (RPE)/choroid from non-visually impaired post-mortem donors, by using smallRNAseq on a Illumina platform. The aim was to establish the catalogue of normal retina-expressed miRNAs, determine their relative abundance, and identify miRNA variants (isomiRs).

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miRNA Profiles in patients and controls

Project description:This project analyzes peripheral blood profiles of patients of various diseases and controls.

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Global mapping of short-lived proteins in human cells

Project description:Rapid protein degradation enables cells to quickly modulate protein abundance in response to stimuli. Previous studies have generally sought to delineate basic features of proteome turnover. A focused map of short-lived proteins, however, remains a missing piece of the human proteome. To begin to address this, we combined cycloheximide chase assays with advanced high-throughput quantitative proteomics to map short-lived proteins in four genetically distinct human cell lines. Apparent half-lives of ≤ 8 hr were measured for 1,017 proteins. Systematic analyses revealed general properties of short-lived proteins (e.g., enriched in substrate recognition subunits of E3 ubiquitin ligase complexes, thermally instable, evolutionarily younger). We further quantified 103 proteins with widely different stabilities among cell lines. Of these, we show that truncated forms of ATRX and GMDS were expressed in U2OS and HCT116 cells, respectively, which had shorter half-lives than their full-length counterparts. This study provides a large-scale resource of human short-lived proteins in cultured cells, leading to untapped avenues of protein regulation for therapeutic intervention.

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GENETIC INFLUENCE ON AGE OF MENOPAUSE IN LONG-LIVED INDIVIDUALS

Project description: Not available

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Expression data of health individuals and newly diagnosed multiple myeloma

Project description:Multiple myeloma is a multi-stage disease. Based on its laboratory and clinical presentation it can be summarized as MGUS, smoldering myeloma, and multiple myeloma. Previous studies have shown that the expression levels of miRNAs in different stages of the disease are different. This study analyzes the expression levels of miRNAs in healthy individuals and myeloma serum exosomes. We used microarrays to detail the miRNAs expressionin between 12 healthy individuals and 12 multiple myeloma and identified distinct classes of dys-regulated genes.

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