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The cellular response to the deprivation of L-phenylalanine from the medium in the cultivation of SAS, a squamous carcinoma cell line.

ABSTRACT: To optimize the efficacy of boron neutron capture therapy (BNCT), we investigated the optimal conditions for maximizing the uptake of boronophenylalanine (BPA), an analog of L-phenylalanine (L-Phe), in tumor cells. In the cultivation of SAS cells, an amplified accumulation of BPA was observed under 24 hours of L-Phe deprivation, which resulted in an enhancement of BNCT efficiency. Consequently, we conducted a comprehensive analysis of the cellular response of SAS under L-Phe restriction by RNA-seq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE279292 | GEO | 2025/12/31

REPOSITORIES: GEO

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The cellular response to the deprivation of L-phenylalanine from the medium in the cultivation of HaCaT, a keratynocyte cell line.

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