Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

H3K27me3 ChIP sequencing on inner ear organ of Corti from WT and Bmi1 KO neonatal mice

ABSTRACT: We conducted ChIP sequencing for H3k27me3 mark on inner ear organ of Corti from WT and Bmi1 KO neonatal mice, thereby clarifying the epigenetic mechanisms by which Bmi1 impacts auditory cell fate.

ORGANISM(S): Mus musculus

PROVIDER: GSE279539 | GEO | 2025/09/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Chromatin accessibility (ATAC-seq) analysis on inner ear organ of Corti from WT and Bmi1 KO neonatal mice

Project description:Clarify changes in chromatin accessibility regions after Bmi1 knockout by performing ATAC-seq on Bmi1 KO and WT organ of Corti from neonatal mice, providing a foundation for integrated analysis of epigenetics and transcriptome sequencing"

2025-09-30 | GSE279758 | GEO

H3K27me3 ChIP sequencing on inner ear organ of Corti from WT and Bmi1 KO neonatal mice

Project description:H3K27me3 ChIP sequencing on inner ear organ of Corti from WT and Bmi1 KO neonatal mice

| PRJNA1173212 | ENA

Transcriptome sequencing samples of the Bmi1 knockout and wildtype neonatal mouse organ of Corti.

Project description:Clarify the transcriptome changes in the inner ear cochlea after Bmi1 knockout

2025-09-30 | GSE279541 | GEO

Chromatin accessibility (ATAC-seq) analysis on inner ear organ of Corti from WT and Bmi1 KO neonatal mice

Project description:Chromatin accessibility (ATAC-seq) analysis on inner ear organ of Corti from WT and Bmi1 KO neonatal mice

| PRJNA1174210 | ENA

Inner ear hair cell proteome

Project description:The mammalian inner ear subserves auditory and vestibular sensations via highly specialized cells and proteins. We show that sensory hair cells (HCs) employ hundreds of uniquely or highly expressed proteins for processes involved in transducing mechanical inputs, stimulating sensory neurons, and maintaining structure and function of these post-mitotic cells. Our proteomic analysis of purified HCs extends the existing HC transcriptome, revealing undetected gene products and isoform-specific protein expression. Comparison with mouse and human databases of genetic auditory/vestibular impairments confirms the critical role of the HC proteome for normal inner ear function, providing a cell-specific pool of candidates for novel, important HC genes. Several proteins identified exclusively in HCs by proteomics and by immunohistochemistry map to human genetic deafness loci, potentially representing new deafness genes.

2016-05-23 | MSV000079756 | MassIVE

Inner ear expression data from pooled inner ear tissue from stages 56,57,58 Xenopus laevis larval inner ears

Project description:The inner ear continues to grow and develop until the auditory and vestibular systems reach full maturity and all of the genes involved in this process have yet to be identified. Previous gene based analysis have primarily focused on the early developmental stages following induction and initial formation of the inner ear. The aim of this study is to identify new candidate genes for inner ear development. Microarrays were used to produce expression profiles from larval stages 56,57,58 of the Xenopus laevis inner ear. The data produced from this work represent an annotated resource that can be utilized by the Xenopus community to provide candidates for further functional analysis. Xenopus inner ears were isolated from larval animals for RNA extraction and hybridization to Affymetrix GeneChip microarrays.

2016-02-29 | E-GEOD-73829 | biostudies-arrayexpress

Inner ear expression data from pooled inner ear tissue from stages 50,51,52 Xenopus laevis larval inner ears

Project description:The inner ear continues to grow and develop until the auditory and vestibular systems reach full maturity and all of the genes involved in this process have yet to be identified. Previous gene based analysis have primarily focused on the early developmental stages following induction and initial formation of the inner ear. The aim of this study is to identify new candidate genes for inner ear development. Microarrays were used to produce expression profiles from larval stages 50,51,52 of the Xenopus laevis inner ear. The data produced from this work represent an annotated resource that can be utilized by the Xenopus community to provide candidates for further functional analysis.

2016-12-31 | GSE73828 | GEO

Inner ear expression data from pooled inner ear tissue from stages 56,57,58 Xenopus laevis larval inner ears

2016-02-29 | GSE73829 | GEO

Inner ear exosomes and their potential use as biomarkers

Project description:Exosomes are nanovesicles involved in intercellular communications. They are released by a variety of cell types; however, their presence in the inner ear has not been described in the literature. The aims of this study were to determine if exosomes are present in the inner ear and, if present, characterize the changes in their protein content in response to ototoxic stress. In this laboratory investigation, inner ear explants of 5-day-old Wistar rats were cultured and treated with either cisplatin or gengentamicin. Exosomes were isolated using ExoQuick, serial centrifugation, and mini-column methods. Confirmation and characterization of exosomes was carried out using transmission electron microscopy (TEM), ZetaView, BCA protein analysis, and proteomics. Vesicles with a typical size distribution for exosomes were observed using TEM and ZetaView. Proteomic analysis detected typical exosome markers and markers for the organ of Corti. There was a statistically significant reduction in the exosome protein level and number of particles per cubic centimeter when the samples were exposed to ototoxic stress. Proteomic analysis also detected clear differences in protein expression when ototoxic medications were introduced. This is the first report describing exosomes derived from the inner ear. Because these exosomes varied in number and protein composition when the inner ear was exposed to ototoxic stress, the exciting possibility exists that they might be used as biomarkers to monitor inner ear function.

2018-07-04 | PXD009483 | Pride

The Hippo pathway and p27Kip1 cooperate to suppress sensory receptor regeneration in the organ of Corti and the retina.

Project description:The mammalian auditory sensory organ, the organ of Corti, has no capacity for regenerating lost hair cells, leading to permanent hearing impairment. In this study, we demonstrate that auditory supporting cells resist Yap activation after Hippo inhibition and uncover the molecular mechanism maintaining quiescence in the adult cochlear supporting cells.

2025-04-23 | GSE268504 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data