Unknown

Dataset Information

45

CNVs in spermatogenic failure


ABSTRACT: To determine the involvement of Copy Number Variants (CNVs) in the origin of male infertility, patients with idiopathic severe oligozoospermia, Sertoli-cell-only syndrome and controls with normozoospermia were analysed by array CGH using the 244A/400K array sets (Agilent Technologies). Overall design: Comparison of 89 infertile male patients with severe oligozoospermia (≤5 x Mill./ml sperm concentration and ≤10 Mill. total sperm count) and 37 with azoospermia due to complete, bilateral Sertoli-cell-only syndrome (SCOS) with 100 healthy controls with normal semen parameters (≥20 Mill./ml sperm concentration, ≥40 Mill. total sperm count, ≥2 ml semen volume, ≥50% of a+b or ≥25% a motility, high percentage of normal forms (≥10%)). Patients with recurring, patient-specific and mostly private, sex-chromosomal CNVs (29 with OAT and 17 with SCOS) are reported as possibly causing spermatogenic failure.

INSTRUMENT(S): Agilent-014693 Human Genome CGH Microarray 244A (Feature number version)

ORGANISM(S): Homo sapiens  

SUBMITTER: Frank Tüttelmann  

PROVIDER: GSE27965 | GEO | 2011-03-17

SECONDARY ACCESSION(S): PRJNA137757

REPOSITORIES: GEO

Similar Datasets

2011-03-17 | E-GEOD-27965 | ArrayExpress
| GSE108194 | GEO
2014-07-03 | E-GEOD-6872 | ExpressionAtlas
2007-11-11 | E-GEOD-6872 | ArrayExpress
| GSE6872 | GEO
2007-04-27 | GSE6967 | GEO
2007-04-27 | GSE6968 | GEO
2013-12-09 | E-GEOD-43586 | ArrayExpress
2019-02-22 | PXD010695 | Pride
| phs001777 | dbGaP