Gene expression profile at single cell level of human control, MPHOSPH8-deficient and MORC2-deficient cerebral organoids at day 27.

ABSTRACT: To translate our mouse data and to model the role of MPHOSPH8 and MORC2 in human brain development, we generated human three-dimensional (3D) cerebral organoids lacking MPHOSPH8 and MORC2. These cerebral organoids were compared to control organoids by single cell RNA sequencing (scRNA-seq) to analyze the cell composition and expression of clustered protocadherins.

ORGANISM(S): Homo sapiens

PROVIDER: GSE279721 | GEO | 2024/10/18

REPOSITORIES: GEO