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G3BP1::CSF1R: a new and actionable gene fusion in acute megakaryoblastic leukemia

ABSTRACT: Here we report a novel targetable G3BP1::CSF1R fusion in acute megakaryoblastic leukemia. The fusion promotes cytokine-independent growth, leukemic engraftment and megakaryocytic commitment by repressing Kruppel-like factor 1. Disruption of juxta-membrane domain aggravates CSF1R kinase activity and dictates the leukemia phenotype.

ORGANISM(S): Homo sapiens

PROVIDER: GSE279844 | GEO | 2025/10/08

REPOSITORIES: GEO

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