Genomics

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ATAC-seq of human plasmacytoid dendritic cells in adult and elderly donors


ABSTRACT: Aging is associated with profound changes in immune cell function. To investigate how aging impacts plasmacytoid dendritic cells (pDCs), we profiled purified pDCs from healthy adult (20–40 years) and elderly (>65 years) human donors. Using bulk RNA-seq (GSE269411) and bulk ATAC-seq (GSE279911), we identified transcriptional and epigenetic changes that occur with age. These datasets provide a resource to explore age-associated alterations in pDC identity, gene regulation, and chromatin accessibility.

ORGANISM(S): Homo sapiens

PROVIDER: GSE279911 | GEO | 2025/06/13

REPOSITORIES: GEO

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