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ChIP-seq analysis for STAT3 targets downstream of LIF signaling in liver ischemia-reperfusion injury

ABSTRACT: LIF is a pleotropic cytokine and its role in liver ischemia-reperfusion injury (IRI) remains unexplored. Utilizing wildtype (WT) and myeloid cell-specific knockout (KO) mice, we demonstrate that the transcription of LIF is activated in myeloid cells and promotes LIFR-induced STAT3 activation in hepatocytes during liver IRI. To understand the downstream targets of STAT3, we performed ChIP-seq analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE279970 | GEO | 2025/12/03

REPOSITORIES: GEO

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