Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Next Generation Sequencing assesses 53BP1-regulated gene expression profiling in hTRET-RPE1 cells

ABSTRACT: The goal of this experiment is to analyze global gene expression profiles after depletion of 53BP1

ORGANISM(S): Homo sapiens

PROVIDER: GSE280049 | GEO | 2025/08/11

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Next Generation Sequencing assesses E2F7-regulated gene expression profiling

Project description:The goal of this experiment is to analyze global gene expression profiles during the cell cycle after acute depletion of E2F7.

2018-03-18 | GSE107216 | GEO

Next Generation Sequencing Analysis of Wild Type and 53BP1-/- Transcriptomes in B lymphocytes

Project description:Absence of 53BP1 influences the profile of DNA rearrangements in B lymphocytes.To determine whether the differences in translocation partner choice were due to differences in transcription, we compared the transcriptome of 53BP1 deficient and wild-type B cells by RNA-Seq and Polymerase II chromatin immunoprecipitation sequencing (ChIP-Seq). Analysis of total mRNA and PolII loading in the presence or absence of 53BP1 in activated B lymphocytes

2013-02-12 | E-GEOD-42350 | biostudies-arrayexpress

Next Generation Sequencing assesses 53BP1-regulated gene expression profiling in hTRET-RPE1 cells

Project description:Next Generation Sequencing assesses 53BP1-regulated gene expression profiling in hTRET-RPE1 cells

| PRJNA1176036 | ENA

Next Generation Sequencing Analysis of Wild Type and 53BP1-/- Transcriptomes in B lymphocytes

2013-02-12 | GSE42350 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of ZEB1-Regulated Transcriptomes

Project description:The goal of this study is to analyze the transcripts regulated by ZEB1.

2017-08-10 | GSE102337 | GEO

Phosphorylation of 53BP1 by ATM enforce neurodevelopmental programs in cortical organoids

Project description:53BP1 is a well-established DNA damage repair factor that has recently been shown to regulate gene expression and critically influence tumor suppression and neural development. For gene regulation, how 53BP1 is regulated remains unclear. Here, we showed that 53BP1-serine 25 phosphorylation by ATM is required for neural progenitor cell proliferation and neuronal differentiation in cortical organoids. 53BP1-serine 25 phosphorylation dynamics controls 53BP1 target genes for neuronal differentiation and function, cellular response to stress, and apoptosis. Beyond 53BP1, ATM is required for phosphorylation of factors in neuronal differentiation, cytoskeleton, p53 regulation, and ATM, BNDF, and WNT signaling pathways for cortical organoid differentiation. Overall, our data suggest that 53BP1 and ATM control key genetic programs required for human cortical development.

2024-08-11 | GSE231321 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of ISL1 Regulated Transcriptomes

Project description:The goal of this study is to analyze the transcriptome profiling (RNA-seq) after ISL1 knockdown. The objective of this study is to elucidate the mechanisms of ISL1 in gastric carcinogenesis, RNA-Seq is performed in BGC823 cells with stable ISL1 knockdown. Comparison and identification of the candidate genes based on the intersection of RNA-seq showed that upregulated and downregulated genes had ISL1-bound regions.

2021-03-24 | GSE147006 | GEO

53BP1 genomic binding

Project description:53BP1 binding analysis in HeLa cells

| PRJEB12222 | ENA

NEAT1 Modulates the TIRR/53BP1 Complex to Maintain Genome Integrity

Project description:Tudor Interacting Repair Regulator (TIRR) is an RNA-binding protein (RBP) that interacts directly with 53BP1, restricting its access to DNA double-strand breaks (DSBs) and its association with p53. We utilized iCLIP to identify RNAs that directly bind to TIRR within cells, identifying NEAT1_1, the short isoform of the long noncoding RNA NEAT1, as the primary RNA partner. The high affinity of TIRR for NEAT1_1 is due to prevalent G-rich motifs in NEAT1_1. This interaction destabilizes the TIRR/53BP1 complex, promoting 53BP1's function. NEAT1_1 is enriched during the G1 phase of the cell cycle, thereby ensuring that TIRR-dependent inhibition of 53BP1’s function is cell cycle-dependent. TDP-43, an RBP that is implicated in neurodegenerative diseases, modulates the TIRR/53BP1 complex by promoting NEAT1_1 production. Together, we infer that NEAT1_1, and factors regulating NEAT1_1, may impact 53BP1-dependent DNA repair processes, with implications for a spectrum of diseases.

2024-09-04 | GSE276206 | GEO

Next Generation Sequencing Quantitative Analysis of Srf-regulated Transcriptomes in mouse cardiomyocytes during cardiomyocyte maturation [exp2]

Project description:The goal of this study is to analyze the impact of Srf overexpression on transcription during cardiomyocyte maturation in mouse

2018-09-24 | GSE116030 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data