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Functional characterization of Central Nervous System (CNS) and peripheral immune responses in Alzheimer's Disease after Bacillus Calmette Guerin (BCG) vaccination in older adults.

ABSTRACT: Cerebrospinal Fluid cells collected from older adults before and after BCG vaccination were studied for evaluating celltype specific functional responsivity to stimulation with antigens. Peripheral blood mononuclear cells were also studied to compare the peripheral and central nervous system (CNS) responsivities.This datase is part of the following. NCT04507126 - A Pilot Study of the Effects of Bacillus Calmette-Guérin (BCG) Immunization on Cerebrospinal Fluid and Blood-based Biomarkers in Older Adults - ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04507126 NCT05004688 - A Trial to Evaluate the Effects of BCG in Adults With MCI and Mild-to-Moderate AD - - ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05004688

ORGANISM(S): Homo sapiens

PROVIDER: GSE280720 | GEO | 2026/04/27

REPOSITORIES: GEO

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scRNA-seq analyses of cerebrospinal fluid (CSF) cells in older adults with or without Alzheimer's disease after Bacillus Calmette Guerin (BCG) vaccination.

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