Fam170a deficiency causes male infertility

ABSTRACT: During spermiogenesis, nucleus condensation packages genomic DNA into tiny sperm heads by histone-to-protamine chromatin remodeling process, which is essential to male fertility. However, this process involving key events and regulators is still poorly understood. Herein, we report that Fam170a orchestrates the histone-to-protamine chromatin remodeling process by interacting with its associated proteins and mediating its associated gene expression.

ORGANISM(S): Mus musculus

PROVIDER: GSE280742 | GEO | 2024/11/10

REPOSITORIES: GEO