Gonadal sex reversal at single-cell resolution in Znrf3-deficient mice

ABSTRACT: Early gonadal-mesonephros tissues give rise to the developing gonad, with potential to diverge towards either a testis or ovarian gonadal fate. ZNRF3 mutant homozygotic mice develop a variable sex reversal previously uncharacterised at the single cell level. We used scRNA-Seq to compare XX and XY WT C57BL/6J mouse gonads to ZNRF3-deficient mice across multiple timepoints, during and after initial sex determination.

ORGANISM(S): Mus musculus

PROVIDER: GSE280999 | GEO | 2024/11/29

REPOSITORIES: GEO